Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

847
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
847
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

745
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
745
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

367
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
367
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

572
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
572
Longitudinal Studies01:26

Longitudinal Studies

446
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
446
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

2.7K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The social environment and cognitive aging over the life course: laying out critical concepts and research gaps.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Differences in the prevalence and patterns of dementia risk factors across 14 countries and regions: a harmonised cross-national analysis.

The lancet. Healthy longevity·2026
Same author

How do women respond to increased care needs of their parents? The economic costs of informal caregiving.

Journal of the economics of ageing·2026
Same author

Risk and protective factors for cognitive decline in older adults from a nationally representative sample in India: Results from the LASI-DAD.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

The cost of dementia in the United States in 2026.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Urban greenspace and dementia: Measures, mechanisms, and methodological guidance.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

Related Experiment Video

Updated: Jan 8, 2026

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.4K

Cardiometabolic-Inflammatory Risk Factors and Cognitive Decline Among Older Indians-Report From a Nationally

Joyita Banerjee1, Jung Ki Kim2, Emma Nichols1

  • 1Center for Economic and Social Research, University of Southern California, Los Angeles, California, USA.

Journal of the American Geriatrics Society
|December 16, 2025
PubMed
Summary

Cardiometabolic risk factors like high blood pressure and elevated HbA1c significantly increase the risk of cognitive decline and mortality in older Indians. Addressing these factors may help prevent cognitive impairment and improve longevity.

Keywords:
cardiometabolic riskcognitive declinehypertensionhyperuricemialongitudinal data

More Related Videos

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.4K
Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

14.1K

Related Experiment Videos

Last Updated: Jan 8, 2026

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.4K
Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.4K
Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

14.1K

Area of Science:

  • Gerontology
  • Cardiology
  • Neurology
  • Public Health

Background:

  • Rising rates of cardiometabolic diseases in India are linked to increased late-life cognitive impairment.
  • This study investigates the connection between cardiometabolic risk factors and cognitive decline in older Indian adults.

Purpose of the Study:

  • To examine the longitudinal associations between baseline cardiometabolic risk factors and subsequent cognitive decline.
  • To identify key risk factors contributing to cognitive impairment and mortality in an aging Indian population.

Main Methods:

  • Longitudinal data from 1554 participants of the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia (LASI-DAD) were analyzed.
  • Cognitive decline was defined as an annual decline in a summary cognitive score.
  • Multivariate multinomial logistic regression was employed to assess associations between cardiometabolic risk markers and cognitive decline/mortality.

Main Results:

  • Significant cognitive decline was associated with elevated blood pressure (OR: 1.7), elevated HbA1c (OR: 1.1), being overweight (OR: 1.4), and elevated uric acid (OR: 1.2).
  • Hypertension increased mortality risk by 1.5 times, while diabetes and elevated pro-brain natriuretic peptide increased it by 1.2 and 1.8 times, respectively.
  • At baseline, high prevalence of elevated homocysteine (71.7%), elevated blood pressure (44.4%), and elevated HbA1c (23%) were observed.

Conclusions:

  • Cardiometabolic risk factors are significant predictors of cognitive decline and mortality in older Indian adults.
  • The findings highlight modifiable risk factors that can inform public health policies for cognitive health and aging.
  • Longitudinal data from LASI-DAD provide crucial insights into the relationship between cardiometabolic health and cognitive aging in India.