Reference ranges of blood glucose values in healthy term neonates in their first days of life: a systematic review and meta-analysis
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View abstract on PubMed
Summary
This summary is machine-generated.Neonatal hypoglycaemia is common, but distinguishing it from normal glucose changes is hard. This study defines normal blood glucose levels in healthy newborns in the first 72 hours, aiding personalized monitoring.
Area Of Science
- Neonatal Medicine
- Metabolic Disorders
- Clinical Chemistry
Background
- Neonatal hypoglycaemia is the most common metabolic disorder in early life.
- Distinguishing physiological from pathological hypoglycaemia is challenging due to limited data.
- Persistent low glucose levels can cause long-term neurodevelopmental issues.
Purpose Of The Study
- To define time-stratified reference blood glucose values in healthy term neonates within the first 72 hours of life.
- To generate a normalcy curve for neonatal glucose levels.
- To aid in differentiating normal glucose fluctuations from pathological hypoglycaemia.
Main Methods
- Systematic review and meta-analysis of original studies.
- Searched PubMed, EMBASE, and Web of Science for relevant data.
- Analyzed glucose patterns using random-effect models and meta-regression to create a normalcy curve.
Main Results
- Included 39 studies with 8538 neonates.
- Generated a normalcy curve showing dynamic glucose trends.
- Median glucose dropped to 3.1 mmol/L within 2 hours, stabilized around 3.2 mmol/L up to 12 hours, and reached 3.6 mmol/L by 36-72 hours.
Conclusions
- Neonatal glucose levels change dynamically in the first 72 hours, with a nadir at 2 hours.
- The 10th percentile serves as a potential lower limit of normal.
- A dynamic, percentile-based interpretation can improve personalized glucose management in neonates.
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