Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Temporal changes in cortisol secretion and their association with long-term outcomes in benign adrenal incidentalomas: a retrospective cohort study.

The lancet. Diabetes & endocrinology·2026
Same author

Impact of postoperative hydrocortisone replacement dose on health-related quality of life and metabolic parameters in patients with cured Cushing's syndrome: randomized, open-label, controlled trial.

Endocrine·2026
Same author

Changes in General Movements During Early Intensive Rehabilitation in High-Risk Infants with Structural Brain Injury: A Preliminary Study.

Children (Basel, Switzerland)·2026
Same author

Clinicopathological Characteristics and BAP1 Expression in an Enucleation-Based Uveal Melanoma Cohort: A Single-Center Croatian Experience with Long-Term Follow-Up.

Cancers·2026
Same author

Clinical predictors of outcome in advanced adrenocortical carcinoma: a multicenter international ENSAT study.

European journal of endocrinology·2026
Same author

The Clinical Spectrum and Management of Ectopic Cushing's Syndrome: A 12-Year Single-Center Experience.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2026

Related Experiment Video

Updated: Jun 19, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

19.4K

Rethinking the Long-Term Follow-Up Strategy for Non-Functioning Pituitary Neuroendocrine Tumours in a Real-World

Mirsala Solak1, Ivana Kraljević1,2, Roman Brekalo3

  • 1Department of Endocrinology, University Hospital Centre Zagreb, Zagreb, Croatia.

Clinical Endocrinology
|December 16, 2025
PubMed
Summary

Postoperative surveillance for non-functioning pituitary neuroendocrine tumours (NF-PiTNETs) can be optimized. A risk-adapted MRI schedule reduces imaging by 36% while ensuring patient safety for NF-PiTNETs.

Keywords:
MRI surveillancenon‐functioning pituitary neuroendocrine tumourrecurrenceresidual tumour progressionrisk stratification

More Related Videos

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
09:53

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

4.1K
Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection
02:22

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Published on: April 12, 2024

834

Related Experiment Videos

Last Updated: Jun 19, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

19.4K
Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
09:53

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

4.1K
Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection
02:22

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Published on: April 12, 2024

834

Area of Science:

  • Endocrinology
  • Neurosurgery
  • Oncology

Background:

  • Non-functioning pituitary neuroendocrine tumours (NF-PiTNETs) require long-term monitoring after surgery.
  • Understanding tumour behaviour is crucial for effective surveillance strategies.

Purpose of the Study:

  • To evaluate the long-term behaviour of NF-PiTNETs post-surgery.
  • To develop a risk-adapted MRI surveillance plan based on real-world data.

Main Methods:

  • Retrospective cohort study of 174 adults with NF-PiTNETs.
  • Minimum 36-month follow-up with serial MRI to assess residual tumour and recurrence.
  • Multivariable Cox proportional hazards models used to identify predictors.

Main Results:

  • Residual tumour occurred in 61.5% and progressed in 27.1%.
  • Recurrence in completely resected tumours was 22.4%.
  • A risk-adapted schedule could reduce MRI scans by 36% without compromising safety.

Conclusions:

  • Tumour progression and recurrence have distinct temporal patterns.
  • Early imaging is vital for residual tumours; delayed imaging may suffice for complete resections.
  • A tailored follow-up protocol balances imaging burden and patient safety.