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Basic research on quercetin in liver cancer: Progress and perspectives.

Binbin Liu1, Yunfeng Yu, Ruoyu Wang

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|December 16, 2025
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Quercetin, a natural flavonoid, shows promise in inhibiting liver cancer by inducing apoptosis and reducing proliferation. Nano-delivery systems are being developed to improve its poor solubility for better clinical application.

Keywords:
action mechanismantitumor effecthepatocellular carcinoma (hcc)liver cancerquercetin

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Area of Science:

  • Natural product chemistry
  • Oncology
  • Pharmacology

Background:

  • Quercetin is a plant flavonoid with demonstrated anticancer properties.
  • It effectively inhibits liver cancer progression by promoting apoptosis and suppressing proliferation, migration, and invasion.
  • Quercetin also shows potential in overcoming multidrug resistance in combination therapies.

Purpose of the Study:

  • To review recent advancements in quercetin-based liver cancer therapeutics.
  • To explore mechanistic studies, clinical trials, and nano-delivery innovations.
  • To summarize safety assessments and Traditional Chinese Medicine mechanisms of quercetin.

Main Methods:

  • Literature review of preclinical and clinical studies on quercetin in liver cancer.
  • Analysis of nano-delivery systems designed to enhance quercetin bioavailability.
  • Examination of safety data and Traditional Chinese Medicine (TCM) related mechanisms.

Main Results:

  • Quercetin exhibits significant inhibitory effects on liver cancer cell apoptosis, proliferation, migration, and invasion.
  • Nano-delivery systems show promise in overcoming quercetin's poor water solubility and oral bioavailability.
  • Combination therapies with quercetin can reduce multidrug resistance and enhance anticancer efficacy.

Conclusions:

  • Quercetin holds significant therapeutic potential for liver cancer, supported by mechanistic and preclinical data.
  • Overcoming pharmacokinetic limitations through nano-delivery is crucial for clinical translation.
  • Further research and systematic safety evaluations are necessary for the clinical application of quercetin in liver cancer treatment.