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Accessory Structures of the Skin: Sebaceous Glands01:21

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Related Experiment Video

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Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid
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Reticulated acanthoma with sebaceous differentiation: A case report.

Wan-Ting Yu1, Qian Zhang, Hong Shen

  • 1Department of Dermatology, Hangzhou Third People's Hospital, Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.

Medicine
|December 16, 2025
PubMed
Summary

Reticulated acanthoma with sebaceous differentiation (RASD) is a rare skin tumor. This case found no link to Muir-Torre syndrome (MTS) but recommends testing to rule it out.

Keywords:
DNA mismatch repair proteinsMuir-Torre syndromeimmunohistochemistryreticulated acanthoma with sebaceous differentiationsebaceous gland neoplasms

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Area of Science:

  • Dermatopathology
  • Oncology

Background:

  • Reticulated acanthoma with sebaceous differentiation (RASD) is a rare benign cutaneous neoplasm.
  • Its association with Muir-Torre syndrome (MTS) is debated due to scarcity.

Purpose of the Study:

  • To report a case of RASD.
  • To investigate potential links to MTS.

Main Methods:

  • Histopathological and immunohistochemical analysis of a solitary buttock papule.
  • Clinical evaluation for visceral malignancies and family history.
  • Surgical excision and follow-up.

Main Results:

  • Confirmed diagnosis of RASD.
  • Immunohistochemistry showed intact DNA mismatch repair proteins.
  • No evidence of MTS or recurrence after 20 months.

Conclusions:

  • RASD diagnosis relies on histopathology.
  • While this case showed no MTS link, baseline screening (immunohistochemistry, colonoscopy) is advised for RASD patients to exclude MTS.