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Updated: Jan 8, 2026

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
Published on: April 6, 2017
Development and evaluation of a novel nebulized dihydromyricetin formulation: enhanced pulmonary delivery and
Kunyan Xu1,2, Jianing Yang1, Meng Yan3
1Department of Pharmacy, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.
Background:
Respiratory diseases are a major global health burden, and inhalation therapy offers efficient pulmonary targeting and therapeutic effectiveness. Dihydromyricetin (DMY), a natural flavonoid with anti-inflammatory and antiviral activities, shows limited clinical application due to poor solubility, instability, and low oral bioavailability caused by extensive first-pass metabolism.
Methods:
A nebulized inhalation formulation of DMY was developed to enhance solubility, stability, and bioavailability. Pharmacokinetics were evaluated in rats following inhalation and oral administration. Safety was assessed through pulmonary function testing and histological examination of major organs.
Results:
Inhalation delivery significantly improved DMY bioavailability in both lung and systemic circulation compared with oral dosing. No differences in pulmonary function or tissue morphology were observed between the inhalation and saline groups after short-term administration, suggesting preliminary safety, which warrants further investigation.
Conclusion:
The nebulized DMY formulation demonstrates enhanced bioavailability, effective pulmonary targeting, and favorable safety, providing a promising therapeutic strategy for respiratory diseases.
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