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Related Concept Videos

Cellular Adaptation II: Hypertrophy01:26

Cellular Adaptation II: Hypertrophy

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Hypertrophy is the increase in the size of individual cells, resulting in the enlargement of a tissue or organ. Unlike hyperplasia, which involves an increase in cell number, hypertrophy is characterized by an increase in cell volume. This process often occurs in response to higher functional demand or hormonal stimulation, leading to the production of more structural proteins and organelles, thereby enhancing the cells' work capacity.There are two primary types of hypertrophy:...
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Related Experiment Video

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Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation
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Decoding Short- and Long-Term Cellular Adaptations to Cr(VI) Exposure Through High-Throughput Transcriptomics.

I-Jeng Yeh1,2, Chih-Yang Wang3,4,5, Nam Nhut Phan6

  • 1Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.

International Journal of Medical Sciences
|December 16, 2025
PubMed
Summary
This summary is machine-generated.

Hexavalent chromium (Cr(VI)) exposure triggers distinct molecular changes over time. Short-term exposure causes acute stress, while long-term exposure promotes fibrosis, EMT, and cancer signaling, offering potential biomarker targets.

Keywords:
Cr(VI)biomarkerscarcinogenesishexavalent chromiumoxidative stresstranscriptomics

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Area of Science:

  • Environmental Toxicology
  • Molecular Carcinogenesis
  • Transcriptomics

Background:

  • Hexavalent chromium (Cr(VI)) is a known carcinogen.
  • The time-dependent molecular effects of Cr(VI) exposure are not well understood.

Purpose of the Study:

  • To investigate the transcriptional responses to acute versus chronic Cr(VI) exposure.
  • To identify molecular pathways and potential biomarkers associated with Cr(VI) carcinogenesis.

Main Methods:

  • Integrated analysis of two transcriptomic datasets (GSE16349 and GSE24025).
  • MetaCore pathway enrichment analysis.
  • Protein-protein interaction (PPI) network analysis.

Main Results:

  • Identified 250 differentially expressed genes common to both short-term and long-term exposure.
  • Short-term exposure activated acute stress responses.
  • Long-term exposure induced pathways related to fibrosis, epithelial-mesenchymal transition (EMT), and oncogenic signaling.
  • Identified potential key hub genes as biomarkers.

Conclusions:

  • Cr(VI) exposure leads to distinct molecular trajectories over time.
  • Findings provide insights into Cr(VI)-induced carcinogenesis.
  • Identified potential targets for preventive and therapeutic interventions.