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Process characterisation of continuous ring layer wet granulation at small scale.

Lukas Bahlmann1,2, Jan Henrik Finke1,2, Arno Kwade1,2

  • 1Institute for Particle Technology (iPAT), Technische Universität Braunschweig, Volkmaroder Straße 5, 38104 Braunschweig, Germany.

International Journal of Pharmaceutics: X
|December 16, 2025
PubMed
Summary
This summary is machine-generated.

Ring layer granulation offers continuous pharmaceutical production. This study investigated a lab-scale Granucon granulator, finding moisture content significantly impacts granule quality and morphology.

Keywords:
Continuous manufacturingMicrostructureProcess parametersRing layerWet granulation

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Area of Science:

  • Pharmaceutical Engineering
  • Particle Technology
  • Chemical Engineering

Background:

  • Ring layer granulation is a continuous wet granulation method for pharmaceutical production.
  • Limited fundamental research exists on the ring layer process, often requiring large-scale equipment.
  • A lab-scale Granucon granulator enables small-scale investigations, addressing this knowledge gap.

Purpose of the Study:

  • To investigate the ring layer granulation process using a lab-scale Granucon granulator.
  • To explore the effects of key process parameters on microcrystalline cellulose granulation.
  • To understand the influence of operational settings on granule characteristics.

Main Methods:

  • Utilized a lab-scale Granucon ring layer granulator for continuous wet granulation.
  • Investigated the granulation of microcrystalline cellulose, an insoluble material.
  • Varied process parameters including tip speed, binder supply rate, and solid feed rate.

Main Results:

  • Moisture content was identified as the most critical factor influencing granulation outcomes.
  • Shaft speed and solid feed rate affected granule residence time within the granulator.
  • Shaft speed was crucial for ring formation and significantly impacted granule morphology via mechanical stress.

Conclusions:

  • The lab-scale Granucon granulator is suitable for fundamental studies of ring layer granulation.
  • Process parameter optimization, particularly moisture control, is essential for desired granule properties.
  • Understanding the interplay between operational parameters and mechanical stress is key to controlling granule morphology.