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The Diagnostic and Progressive Value of Serum GSDMD in Patients with Heart Failure: A Retrospective Study

Changmei Wei1, Nan Ding1, Xuexin Liu1

  • 1Department of Medical Laboratory, Hebei General Hospital, Shijiazhuang, Hebei Province, People's Republic of China.

International Journal of General Medicine
|December 16, 2025
PubMed

Insights

Serum Gasdermin D (GSDMD) shows promise as a novel biomarker for early heart failure diagnosis and monitoring disease progression. This study found GSDMD levels correlate with heart failure severity and aid in early detection.

Area of Science:

  • Cardiology
  • Biomarker Discovery
  • Clinical Diagnostics

Background:

  • Heart failure (HF) diagnosis and progression monitoring remain critical clinical challenges.
  • Novel biomarkers are needed for early detection and accurate assessment of HF.
  • Gasdermin D (GSDMD) is implicated in inflammatory processes relevant to cardiovascular disease.

Purpose of the Study:

  • To evaluate serum Gasdermin D (GSDMD) as a potential novel biomarker for early diagnosis of heart failure.
  • To assess the utility of GSDMD in monitoring heart failure disease progression.
  • To compare the diagnostic performance of GSDMD with established biomarkers like NT-ProBNP and ejection fraction (EF).

Main Methods:

  • Retrospective analysis of clinical data and laboratory results from heart failure, other cardiac disease, and healthy control groups.
  • Comparison of serum GSDMD levels across different patient cohorts.
  • Correlation analysis between GSDMD and other clinical indicators.
  • Receiver operating characteristic (ROC) curve analysis to determine diagnostic accuracy.

Main Results:

  • Serum GSDMD levels were significantly different among the three groups and increased with heart failure severity.
  • Serum GSDMD demonstrated a strong correlation with various clinical indicators.
  • GSDMD and NT-ProBNP were identified as independent risk factors, while EF was a protective factor for heart failure.
  • The area under the curve (AUC) for GSDMD in diagnosing heart failure was 0.819, with a combined AUC of 0.986 with NT-ProBNP and EF.

Conclusions:

  • Serum GSDMD is a novel and sensitive biomarker with significant potential for the early diagnosis of heart failure.
  • GSDMD can be valuable in assessing the progression of heart failure.
  • Combined assessment with NT-ProBNP and EF enhances diagnostic accuracy for heart failure.
Abstract

Keywords:
diagnostic valueheart failureserum GSDMD

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