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Updated: Jan 8, 2026

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

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Molecular Mechanism and Application Progress of Circular RNA Regulating Ischemic Stroke Through the Competing

Tian-Pei Wang1, Li-Li Teng1, Minmin Wu1

  • 1Second Clinical Medical College, Heilongjiang University of Chinese Medicine, Harbin 150040, China.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
|December 16, 2025
PubMed

Insights

Circular RNAs (circRNAs) are involved in ischemic stroke (IS) pathology via the competing endogenous RNA (ceRNA) network. This review explores circRNA

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Ischemic stroke (IS) is a leading cause of death and disability.
  • Current treatments for IS have limited effectiveness.
  • Circular RNAs (circRNAs) are implicated in various cellular processes relevant to IS.

Purpose of the Study:

  • To review the molecular mechanisms of circRNAs in IS.
  • To summarize the application progress of circRNAs in IS diagnosis and treatment.
  • To provide a theoretical basis for future research and clinical practice.

Main Methods:

  • Literature review of studies on circRNAs and IS.
  • Analysis of the competing endogenous RNA (ceRNA) regulatory network.
  • Examination of circRNA's role in apoptosis, inflammation, angiogenesis, autophagy, oxidative stress, and neuronal regeneration.

Main Results:

  • CircRNAs regulate key pathological processes in IS through the ceRNA network.
  • circRNA-mediated ceRNA networks offer potential therapeutic targets for IS.
  • Understanding these mechanisms can guide the development of novel diagnostic and therapeutic strategies.

Conclusions:

  • CircRNAs play a significant role in the pathogenesis of ischemic stroke.
  • The ceRNA network is a crucial mechanism through which circRNAs exert their effects.
  • Further research into circRNAs holds promise for improving IS management.

Keywords:
biomarkercircular RNAischemic strokemolecular mechanismtargeted therapy

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