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Updated: Jan 8, 2026
Establishment of a Clinic-based Biorepository
Published on: May 29, 2017
Expression of BMI1 and ERK3 in Oral Squamous Cell Carcinoma and Their Relationship With Tissue Differentiation and
Yan Zhao1, Weiting Hao1, Shuang Wang2
1Department of Stomatology, Xingtai People's Hospital, Xingtai, Hebei, China.
Objective:
To analyze the expression of B-cell-specific Moloney murine leukemia virus insertion site 1 (BMI1) and mitogen-activated protein kinase 3 (ERK3) in the serum of oral squamous cell carcinoma (OSCC) patients and their relationship with tissue differentiation and lymph node metastasis.
Methods:
A total of 200 patients with OSCC from July 2019 to October 2021 were selected as the OSCC group. And 100 healthy physical examination subjects during the same period were selected as the control group according to the 2:1 ratio principle. Serum BMI1 and ERK3 mRNA expression levels were compared between the two groups and across different clinicopathological characteristics in OSCC patients. Their correlations with pathological features were also examined. The expression levels of BMI1 and ERK3 mRNA in the serum of patients with different prognoses in the OSCC group were compared. The prognosis and survival of patients were compared based on different serum levels of BMI1 and ERK3.
Results:
The expression levels of serum BMI1 mRNA and ERK3 mRNA in the OSCC group were higher than those in the control group (p < 0.05). There were significant differences in the expression levels of serum BMI1 mRNA and ERK3 mRNA in patients with different degrees of differentiation, lymph node metastasis, and TNM staging (p < 0.05). The expression levels of serum BMI1 mRNA and ERK3 mRNA were negatively correlated with histological grading and positively correlated with lymph node metastasis and TNM staging (p < 0.05). The expression levels of serum BMI1 mRNA and ERK3 mRNA in surviving patients were lower than those in deceased patients (p < 0.05). Before and after adjusting for lymph node metastasis, TNM staging, and other factors, serum levels of BMI1 mRNA and ERK3 mRNA were still the influencing factors of OSCC prognosis (p < 0.05). The survival rate was significantly lower in the high-expression groups than in the low-expression groups (36.2% vs. 81.3% for BMI1, 39.2% vs. 79.7% for ERK3, p < 0.05 for both).
Conclusion:
The expression levels of serum BMI1 mRNA and ERK3 mRNA in OSCC patients are increased, which is closely related to the pathological characteristics and prognosis of patients. BMI1 and ERK3 are helpful in evaluating the prognosis of OSCC patients.
