Association between new dietary index for gut microbiota and lung cancer: A population-based study

The dietary index for gut microbiota (DI-GM), which reflects microbiota diversity, has not yet been linked to lung cancer. To explore this, we analyzed the relationship between DI-GM and lung cancer using data from the National Health and Nutrition Examination Survey. This analysis used National Health and Nutrition Examination Survey data from 2007 to 2018. We assessed multicollinearity among the independent variables with variance inflation factors, then performed weighted logistic regression, subgroup analysis, and applied a restricted cubic spline model to explore the relationship between DI-GM and lung cancer. The study included 22,473 adults aged 20 and older. The adjusted findings indicated that a higher DI-GM was associated with a reduced likelihood of lung cancer. variance inflation factors confirmed the absence of multicollinearity. After adjusting for potential confounders, participants with the highest DI-GM had a 72% lower risk of developing lung cancer compared to those with the lowest scores (OR = 0.28; 95% CI: 0.09-0.84, P = .02). A linear negative correlation was observed between DI-GM and the risk of lung cancer. This cross-sectional investigation revealed a negative relationship between the DI-GM and the likelihood of lung cancer.