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Septal Embolization Using Ethylene Vinyl Alcohol Copolymer in Hypertrophic Obstructive Cardiomyopathy: 1-Year

Rômulo Francisco de Almeida Torres1, Sarah Fagundes Grobe1, Larissa de Oliveira Rengel de Souza1

  • 1Hospital São Marcelino Champagnat, Curitiba, Brazil.

JACC. Case Reports
|December 16, 2025
PubMed

Insights

Onyx embolization offers a safe alternative to alcohol septal ablation for hypertrophic obstructive cardiomyopathy (HOCM). This nonalcoholic agent successfully reduced septal hypertrophy and improved symptoms in a patient unsuitable for surgery.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Medical Devices

Background:

  • Hypertrophic obstructive cardiomyopathy (HOCM) is a genetic heart condition causing left ventricular outflow tract obstruction.
  • Current invasive treatments include surgical myectomy and alcohol septal ablation.
  • Alcohol septal ablation carries risks of cardiotoxicity, arrhythmias, and pacemaker dependency, driving the search for alternatives.
Abstract

Keywords:
EVOHethylene-vinyl alcohol copolymerfibrosishemodynamicshypertrophic cardiomyopathyhypertrophic obstructive cardiomyopathyseptal ablationseptal reduction therapyventricular outflow obstruction

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