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Progress in the Synthesis and Application of Phycocyanin-Based Nanoparticles
Fatemeh Rahmati-Dehkordi1,2,3, Siavash Abdolghaderi4, Felora Ferdosi5
1Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Topics in Current Chemistry (Cham)
|December 16, 2025
Summary
Phycocyanin nanoparticles show promise for treating cancer and microbial infections by targeting key cellular processes. These formulations are effective against various bacteria and parasites, expanding their therapeutic potential.
Area of Science:
- Biochemistry
- Nanotechnology
- Pharmacology
Background:
- Phycocyanin, a phycobiliprotein, possesses known antimicrobial and anticancer properties.
- Nanoparticle formulations of phycocyanin are gaining attention for treating cancers and infectious diseases.
Purpose of the Study:
- To evaluate various phycocyanin-based nanoparticle formulations.
- To emphasize the cellular and molecular pathways involved in their anticancer and antimicrobial therapeutic effects.
Main Methods:
- Review of existing literature on phycocyanin-based nanoparticles.
- Analysis of polymer (chitosan, PLGA, polypyrrole, hydrogel) and non-polymer (liposomes, phytosomes, micelles, microspheres, MnO2, BPQDs) nanoparticle types.
- Investigation of targeted cellular and molecular processes (apoptosis, cell cycle arrest, angiogenesis, metastasis).
Main Results:
- Phycocyanin nanoparticles target diverse cellular and molecular pathways relevant to cancer therapy.
- Demonstrated efficacy against a range of bacteria (e.g., E. coli, S. aureus) and parasites (e.g., Cryptosporidium).
- Various nanoparticle platforms enhance phycocyanin's therapeutic applications.
Conclusions:
- Phycocyanin-based nanoparticles offer a versatile platform for cancer and microbial therapies.
- Understanding the underlying cellular and molecular mechanisms is crucial for optimizing treatment strategies.
- Further research into these nanoparticles holds significant therapeutic potential.
