Impact Of Caloric Intake In Cancer Cachexic Patients On Nandrolone - A Prospective Observational Study

1. To observe the lean body mass, BMI and weight with impact of nutrition over 3 months. 2. To compare percentage increase in weight gain between regular and irregular caloric intake patients.

A prospective observational study was performed at Cancer Centre Hospital over six months from July to December, 2024 which includes a sample size of 197 participants. Participants were divided into regular (=2000 kcal/day) and irregular (<2000 kcal/day) caloric intake groups, with both receiving nandrolone. Weight, BMI, and lean body mass (LBM) were measured monthly for three months.

Statistical analysis was performed using SPSS. Comparative analysis was performed by applying chi-square test. Logistic regression analysis was performed to calculate odds ratios. A p value = 0.05 was considered statistically significant.

Patients with regular caloric intake showed significant improvements: weight increased by 13.0% (vs. 4.3% in irregular group), BMI rose from 18.46 to 20.82 (vs. 18.47 to 19.24), and LBM increased from 83.40 to 86.16 (vs. 83.40 to 83.76). All changes were statistically significant (p<0.05). Socioeconomic status influenced adherence, with higher-income patients more likely to maintain regular intake.

Regular caloric intake combined with nandrolone therapy significantly enhances weight, BMI, and LBM in cancer cachexia patients. Adherence to dietary recommendations is critical for mitigating muscle wasting and improving clinical outcomes. These findings underscore the importance of integrated nutritional and pharmacological interventions in cachexia management.