Prevalence and factors associated with hyperglycemia among children living with HIV on dolutegravir in Kabale district, southwestern Uganda
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View abstract on PubMed
Summary
This summary is machine-generated.Hyperglycemia affects one in five children with HIV on dolutegravir (DTG) treatment in Uganda. Adolescents and children consuming red meat showed higher risks, indicating a need for regular blood sugar monitoring.
Area Of Science
- Pediatrics
- Infectious Diseases
- Endocrinology
Background
- High blood sugar (hyperglycemia) poses significant health risks for children, especially those with undiagnosed or poorly managed conditions.
- Antiretroviral therapy (ART) including dolutegravir (DTG) has been linked to increased hyperglycemia prevalence in adults with HIV.
- Limited data exists on hyperglycemia in children living with HIV who are on DTG-based ART in Uganda.
Purpose Of The Study
- To determine the prevalence of hyperglycemia among children living with HIV on DTG in Uganda.
- To identify factors associated with hyperglycemia in this pediatric population.
Main Methods
- A cross-sectional study involving 271 children under 18 years old receiving DTG-based ART in Kabale district, Uganda.
- Data collection via structured questionnaires and biochemical tests (random blood sugar, HbA1C).
- Statistical analysis using logistic regression to identify associated factors.
Main Results
- The prevalence of hyperglycemia was 20.3% among the studied children.
- Of those with hyperglycemia, 76% had prediabetes and 24% had diabetes mellitus.
- Independent factors associated with hyperglycemia included red meat consumption (AOR: 3.52) and age over 13 years (AOR: 2.61).
Conclusions
- One in five children with HIV on DTG treatment exhibit hyperglycemia, with a significant proportion having diabetes mellitus.
- Adolescents and children consuming red meat are more susceptible to hyperglycemia.
- Routine blood glucose monitoring is recommended for children with HIV on DTG therapy.
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