The relationship between metabolic dysfunction-associated fatty liver disease and hormonal disorders in children: A literature review
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View abstract on PubMed
Summary
This summary is machine-generated.Hormonal imbalances like thyroid dysfunction, insulin resistance, and low vitamin D are common in children with fatty liver disease. Weight loss can improve these issues, highlighting the need for endocrine care.
Area Of Science
- Pediatric Endocrinology
- Hepatology
- Metabolic Disorders
Background
- Metabolic dysfunction-associated fatty liver disease (MAFLD) is increasingly prevalent in children.
- MAFLD is linked to various metabolic and hepatic abnormalities.
- Hormonal disturbances may play a significant role in pediatric MAFLD progression.
Purpose Of The Study
- To review current evidence on hormonal disturbances in pediatric MAFLD.
- To examine the relationship between hormonal changes and liver/metabolic issues.
- To assess the impact of interventions on these hormonal disturbances.
Main Methods
- Comprehensive literature search of PubMed, Scopus, and Web of Science (2015-2025).
- Inclusion of studies on children (0-18 years) with confirmed MAFLD.
- Exclusion of adult studies, small case series, and articles lacking endocrine data.
Main Results
- High prevalence of subclinical hypothyroidism (18-42%), insulin resistance (>65%), low testosterone/SHBG in boys, and vitamin D deficiency (55-70%).
- Hormonal disturbances correlated with elevated liver enzymes and steatosis severity.
- Weight reduction (7-10%) improved insulin resistance, thyroid/sex hormones, and vitamin D status.
Conclusions
- Pediatric MAFLD is a multisystem condition influenced by hormonal dysfunction.
- Comprehensive endocrine evaluation is crucial for standard pediatric MAFLD care.
- Further research is needed, especially in younger children, girls, and diverse populations.
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