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Updated: Jan 8, 2026
Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex
Published on: July 27, 2022
Benzothiazole diimine rhenium(I) '2 + 1' complexes: Synthesis, structural characterization and anticancer activity
Ioanna Roupa1, Michael Kaplanis1, Antonio Shegani1
1Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Center for Scientific Research "Demokritos", 15310 Athens, Greece.
Abstract:
In this work, novel '2 + 1' mixed ligand tricarbonyl ReI complexes of the general type fac-[Re(CO)3(NN)X]0/+, where NN is a diimine ligand bearing the anticancer scaffold of 2-(4'-aminophenyl)benzothiazole, and X is Br- (1), Η2Ο (2), pyridine (3), cyclohexyl isocyanide (4), triphenylphosphine (5) and 1,3,5-triaza-7-phosphaadamantane (6), were synthesized, characterized, and evaluated. This design uses rhenium and phenylbenzothiazole to generate targeted, multipotent metal-based anticancer agents with tunable pharmacokinetics. Except for compound 6, all complexes exhibited IC50 values ranging from 0.19 to 6.28 μM against HeLa (ovarian), MCF-7 (breast), and A431 (epidermoid) cancer cell lines, outperforming cisplatin under the same conditions, while showing evidence of synergistic action between the pharmacophore and the rhenium core. In addition, their interaction with calf thymus DNA was investigated, with the data indicating intercalation. Complex 4, with the most potent anticancer activity, was additionally labeled with 99mTc and exhibited optimal stability and high lipophilicity. Its in vivo biodistribution was studied in healthy and SCID mice bearing MCF-7 xenografts, showing good tumor uptake and retention. Finally, a detailed X-ray crystallographic study of molecular packing revealed a plethora of intermolecular interactions, including hydrogen bonds, π-π overlap, and carbonyl···carbonyl interactions. The high anticancer potency and tumor-targeting properties make these compounds promising anticancer agents.
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