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Updated: Jul 31, 2026
Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
Published on: December 9, 2010
Functional MRI quantitative parameters as biomarkers of proliferation in synovial sarcoma xenografts: A study based
Chengjiang Xu1, Yasmin Mushtaq2, Xiaoge Liu3
1Department of Radiology, The Second Hospital, Dalian Medical University, Dalian, People's Republic of China; Department of Radiology, Zhoushan Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Zhoushan, People's Republic of China.
Purpose:
To determine whether quantitative parameters from diffusion-weighted imaging (DWI), intravoxel incoherent motion (IVIM), and dynamic contrast-enhanced MRI (DCE-MRI) are associated with proliferative activity in synovial sarcoma (SS) xenografts.
Materials And Methods:
Thirty-four synovial sarcoma (SS) xenograft models were established. All mice underwent MRI, including DWI (ADC), IVIM (D, D*, f), and DCE-MRI (Ktrans, Kep, Ve). An MR imaging-pathology correlation method was used to align imaging ROIs with pathological sampling sites. Pearson or Spearman correlation analyses were performed to assess associations between MRI parameters and proliferation-related markers (mitotic count, Ki-67, and PTEN). Differences between high and low groups for each marker were evaluated using independent-sample t-tests or Wilcoxon rank-sum tests. Diagnostic performance was assessed using receiver operating characteristic (ROC) curve analysis, and AUCs were compared with DeLong's test.
Results:
The D value was significantly associated with mitotic count, Ki-67 expression, and PTEN expression (P = 0.022, 0.004, 0.001). Ve showed a positive association with mitotic count (P = 0.007), while Ktrans demonstrated a moderate negative association with PTEN expression (P < 0.001). D and Ve showed moderate ability to distinguish high from low mitotic count (AUC = 0.734 and 0.786). The D value showed moderate differentiation between Ki-67 expression groups (AUC = 0.802), and Ktrans provided moderate discrimination between PTEN expression groups (AUC = 0.813).
Conclusion:
The proliferative activity of SS xenografts could be assessed using quantitative parameters derived from IVIM and DCE-MRI.
