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RNA-binding proteins (RBPs) are crucial regulators of gene expression in angiogenesis, the process of new blood vessel formation. This review explores how RBPs control angiogenic gene pathways by interacting with messenger RNAs (mRNAs).

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Area of Science:

  • Vascular Biology
  • Molecular Biology
  • Gene Regulation

Background:

  • Angiogenesis, the formation of new blood vessels, is vital for development, repair, and cancer.
  • Endothelial cell (EC) migration and proliferation, driven by angiogenic factors, orchestrate this process.
  • RNA-binding proteins (RBPs) posttranscriptionally regulate gene expression, influencing cell behavior.

Purpose of the Study:

  • To review current findings on the roles of RBPs in angiogenesis.
  • To identify knowledge gaps concerning RBP regulation of angiogenic gene pathways.
  • To focus on the molecular mechanisms by which RBPs modulate target messenger RNAs (mRNAs).

Main Methods:

  • Literature review of recent studies on RBPs and angiogenesis.
  • Analysis of RBP interactions with canonical and modified mRNAs.
  • Focus on molecular mechanisms of RBP-mRNA regulation in endothelial cells (ECs) and non-ECs.

Main Results:

  • RBPs significantly modulate angiogenic gene pathways in both ECs and non-ECs.
  • RBPs recognize and regulate both canonical and chemically modified mRNAs.
  • Specific molecular mechanisms of RBP-mRNA regulation in angiogenesis are highlighted.

Conclusions:

  • RBPs are critical regulators of gene expression in angiogenesis.
  • Further research into RBP-mRNA interactions is needed to fully understand their role in vascular biology.
  • Understanding these mechanisms can offer insights into therapeutic strategies for angiogenesis-related diseases.