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Efficacy of perceptual learning among patients with infantile nystagmus: a prospective single-blind randomised

Idan Hecht1,2, Claudia Yahalom3, Ora Abaev4

  • 1Department of Ophthalmology, Shamir Medical Center, Zerifin, Israel idanhe@gmail.com.

The British Journal of Ophthalmology
|December 16, 2025
PubMed

Insights

Repeated visual stimulation with Gabor patches significantly improved vision in patients with infantile nystagmus. This non-invasive treatment enhanced visual acuity and stereopsis, offering a promising option for vision improvement.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Vision Science

Background:

  • Infantile nystagmus (IN) presents limited effective treatment options.
  • Visual perceptual learning is being explored as a potential therapeutic strategy for IN.

Purpose of the Study:

  • To evaluate the efficacy of repeated visual stimulation using Gabor patches in improving vision in patients with infantile nystagmus.

Main Methods:

  • A prospective, randomized, single-blind study (3:1 ratio) involving 36 patients (9-55 years) with IN.
  • The treatment group received approximately 4 months of visual stimulation (30 min, 3-4 times/week) via web-based software.
  • Control group received no treatment during the study period.

Main Results:

  • 46% of treated patients achieved driving-standard visual acuity (20/40) versus 10% of controls.
  • Significant improvements were observed in distance and near best-corrected visual acuity (BCVA) in the treatment group (p<0.001 and p=0.040, respectively).
  • 88% of treated patients without prior stereopsis gained the ability, compared to 25% of controls (p=0.10).

Conclusions:

  • Visual perceptual learning with Gabor patches effectively improved visual acuity and stereopsis in patients with infantile nystagmus.
  • This non-invasive visual stimulation approach shows promise as a novel treatment for enhancing visual function in IN.
  • Further research may establish this as a viable therapeutic option for individuals with infantile nystagmus.
Abstract

Keywords:
Prospective StudiesTreatment otherVisionVisual perception

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