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Related Concept Videos

Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

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Related Experiment Video

Updated: May 15, 2026

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
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Prognostic outcome of extranodal marginal zone B-cell lymphoma: a nationwide cohort.

Su Youn Nam1,2,3, Junwoo Jo4

  • 1Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea. nam20131114@gmail.com.

Scientific Reports
|December 16, 2025
PubMed
Summary

Prognosis for extranodal marginal zone B-cell lymphoma (MALT lymphoma) depends on sex, age, stage, comorbidities, and lifestyle factors. Men, older age, and advanced stage are linked to poorer outcomes, while income and physical activity improve survival.

Keywords:
AgeExtranodal marginal zone B-cell lymphomaPrognostic factorsSex

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Area of Science:

  • Hematology
  • Oncology
  • Epidemiology

Background:

  • Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a distinct subtype of non-Hodgkin lymphoma.
  • Understanding prognostic determinants is crucial for optimizing patient management and treatment strategies.

Purpose of the Study:

  • To investigate prognostic factors influencing survival in patients with MALT lymphoma.
  • To identify key demographic, clinical, and lifestyle determinants of mortality in this patient cohort.

Main Methods:

  • Analysis of 11,730 MALT lymphoma patients from the National Cancer Registry.
  • Kaplan-Meier survival estimates and multivariable Cox proportional hazards models were employed.
  • Factors analyzed included sex, age, SEER stage, comorbidities, household income, physical activity, and body mass index.

Main Results:

  • Female sex, younger age, and early SEER stage were associated with better survival.
  • Male sex, advanced age (≥80 years), metastatic disease, diabetes, cardiovascular, and cerebrovascular diseases were linked to higher mortality.
  • Higher household income, physical activity, and higher body mass index were associated with reduced mortality.
  • Age-specific survival benefits were observed for income, physical activity, smoking, and BMI.

Conclusions:

  • Prognosis in MALT lymphoma is significantly influenced by a combination of patient demographics, disease stage, comorbidities, and lifestyle factors.
  • These findings highlight the importance of a holistic approach to patient care, considering both clinical and non-clinical factors for improved outcomes.