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Author Spotlight: In-Depth Morphometric Examination and Quantification of Native Lens Structure Using Whole Mount Imaging

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Published on: January 19, 2024

In vivo imaging reveals exosome-mediated intercellular communication in lens development.

Jingyu Ma^1,2, Qihang Sun³, Yijia Chen¹

¹State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China.

Communications Biology

|December 16, 2025

Summary

Researchers identified endogenous exosomes in zebrafish lenses, revealing their dynamic movement and role in lens development. This discovery offers insights into lens cell communication and potential therapeutic strategies.

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Area of Science:

Ophthalmology
Cell Biology
Developmental Biology

Background:

Intercellular communication is vital for lens transparency and homeostasis.
Exosomes are key mediators of intercellular communication but their role in the lens is largely unknown.

Purpose of the Study:

To investigate the presence, dynamics, and function of endogenous exosomes in the zebrafish lens.
To elucidate the regulatory pathways and mechanisms of exosome biogenesis and function in lens development.

Main Methods:

Utilized cryaa-driven Cd63-AcGFP labeling for endogenous exosome visualization in zebrafish lenses.
Performed live imaging to observe exosome movement and intercellular transfer.
Investigated the Syntenin-a pathway's role in exosome biogenesis via knockdown experiments.
Assessed the impact of lens progenitor cell-derived extracellular vesicles on lentoid differentiation in vitro.

Main Results:

Successfully visualized and characterized endogenous exosomes within the zebrafish lens.
Demonstrated dynamic exosome movement and potential transfer to adjacent tissues.
Identified Syntenin-a as a regulator of Cd63+ exosome biogenesis in the lens.
Showed that Syntenin-a knockdown impairs lens development and cell differentiation.
Confirmed that ROR1+ lens progenitor cell-derived extracellular vesicles promote lentoid differentiation.

Conclusions:

This study provides the first direct observation of endogenous exosomes in the lens, filling a critical knowledge gap.
Lens cell-derived exosomes, regulated by Syntenin-a, play a significant role in lens development and homeostasis.
Extracellular vesicles from lens progenitor cells can drive lentoid differentiation, suggesting therapeutic potential for modulating the lens microenvironment.