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Prophylactic Intraperitoneal Chemotherapy with Platinum Agents Following Curative Resection for Colorectal Cancer: A
Ahmed Dawood Al Mahrizi1,2, Fatima Mossolem3,4, Erin Major3,4
1Faculty of Medicine & Surgery, University of Malta, Msida, Malta. ahmed.d.almahrizi.22@um.edu.mt.
Background:
Peritoneal recurrence is a significant concern after curative resection of colorectal cancer (CRC), with systemic chemotherapy providing limited prevention. Prophylactic intraperitoneal chemotherapy (PIC) using platinum-based agents offers a potential strategy to reduce recurrence and improve survival.
Objective:
Our objective was to assess the effectiveness of platinum-based PIC in reducing peritoneal recurrence and enhancing survival outcomes when administered during or after curative CRC resection versus surgery alone or standard systemic therapy.
Methods:
We conducted a systematic review and meta-analysis following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. Databases were searched from January 2015 to September 2025 for randomized and comparative studies of adults receiving curative CRC resection with platinum-based PIC versus controls. Primary outcomes were overall survival (OS), disease-free survival (DFS), and peritoneal recurrence. Secondary outcomes were grade 3-4 adverse events and major complications. Random-effects meta-analyses in R used hazard ratios (HRs) for time-to-event outcomes and risk ratios (RRs) for binary outcomes; heterogeneity was assessed via I2.
Results:
In total, 16 studies were included in the qualitative synthesis and seven (three randomized controlled trials, four cohorts; n=1264) in the meta-analysis. Platinum-based PIC improved DFS (HR 0.57; 95% confidence interval [CI] 0.42-0.78, p=0.0004, I2=0%) and trended toward an OS benefit (HR 0.87; 95% CI 0.69-1.12, p=0.28, I2=0%). Peritoneal recurrence was reduced but heterogeneous (RR 0.69; 95% CI 0.29-1.63, p=0.40, I2=85%). No increases were observed in grade 3-4 events (RR 1.26; 95% CI 0.97-1.64, p=0.08, I2=0%) or complications (RR 1.02; 95% CI 0.74-1.39, p=0.91, I2=39%).
Conclusions:
Platinum-based PIC appears to enhance DFS without increasing adverse events or complications. Larger randomized controlled trials with longer follow-up are needed to confirm potential survival benefits and determine optimal protocols.
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