Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

567
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
567
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

518
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
518
Endoscopic Studies I: Bronchoscopy and Thoracoscopy01:30

Endoscopic Studies I: Bronchoscopy and Thoracoscopy

492
Endoscopy is a non-surgical medical technique used to examine a person's internal organs and vessels. This lesson will focus on two types of endoscopic studies: bronchoscopy and thoracoscopy.
Bronchoscopy
Description
Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due...
492
Endoscopic Studies II: Thoracocentesis01:26

Endoscopic Studies II: Thoracocentesis

1.2K
Thoracentesis(Thoracocentesis), commonly known as pleural tap, is a medical procedure where a 22 gauge needle is inserted into the pleural space, the area between the lung and chest wall. This procedure is commonly performed to diagnose or treat various respiratory disorders.
Description
Excess pleural fluid or air may accumulate in some respiratory disorders in the thoracic cavity. To treat pleural effusion, a physician conducts thoracentesis by carefully piercing the chest wall and entering...
1.2K
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

787
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
787

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Salvianolic acid B alleviates depression-like behaviors by reducing neuronal injury and promoting neurogenesis in a manner associated with JAK-STAT signaling pathway inhibition.

Frontiers in neurology·2026
Same author

Externally Controlled In Situ SEM: Multi-Rate Scanning With Signal Regulation and Spatiotemporal Fusion.

Microscopy research and technique·2026
Same author

[Polydatin attenuates high copper induced damage in Atp7b knockout neural stem cells by regulating PPARG mediated ferroptosis].

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences·2026
Same author

ProBDNF promotes LPS-induced pro-inflammatory polarization of alveolar macrophages via the Notch1 signaling pathway.

Immunologic research·2026
Same author

Financial Feasibility of BPaL(M) Under Pretomanid Price Scenarios - China, 2023-2024.

China CDC weekly·2026
Same author

Curdlan-Reinforced Chitosan/Polyacrylate Interpenetrating Hydrogels with Enhanced Mechanical Stability for Gastric Retention and pH-Responsive Drug Release.

Gels (Basel, Switzerland)·2026

Related Experiment Video

Updated: Jan 8, 2026

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia
05:39

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia

Published on: May 26, 2023

2.2K

Effects of penehyclidine hydrochloride on postoperative nausea and vomiting in patients who underwent radical

Ni Wang1, Shu-Hui Hou2, Rui Meng1

  • 1Department of Anesthesiology, Henan Provincial Chest Hospital, Chest Hospital of Zhengzhou University, Zhengzhou, China.

Trials
|December 16, 2025
PubMed
Summary
This summary is machine-generated.

This study investigates Penehyclidine hydrochloride (PHC) for preventing postoperative nausea and vomiting (PONV) in lung cancer surgery patients. We hypothesize PHC will reduce PONV incidence and severity, improving patient outcomes.

Keywords:
Lung cancerPenehyclidine hydrochloridePostoperative nausea and vomitingRandomized controlled trialVideo-assisted thoracoscopic surgery

More Related Videos

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
05:56

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting

Published on: June 21, 2024

1.8K

Related Experiment Videos

Last Updated: Jan 8, 2026

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia
05:39

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia

Published on: May 26, 2023

2.2K
Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
05:56

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting

Published on: June 21, 2024

1.8K

Area of Science:

  • Anesthesiology and Perioperative Medicine
  • Thoracic Surgery
  • Pharmacology

Background:

  • Postoperative nausea and vomiting (PONV) is a frequent complication following radical thoracoscopic lung cancer surgery.
  • PONV leads to patient discomfort, delayed recovery, and increased healthcare expenses.
  • Penehyclidine hydrochloride (PHC), a novel anticholinergic agent, may mitigate PONV due to selective M1 and M3 muscarinic receptor antagonism.

Purpose of the Study:

  • To evaluate the efficacy and safety of Penehyclidine hydrochloride (PHC) in reducing PONV incidence and severity.
  • To assess the impact of PHC on surgeon and patient satisfaction post-surgery.
  • To explore potential adverse effects associated with PHC administration.

Main Methods:

  • A single-center, prospective, double-blind, randomized controlled trial involving 446 patients undergoing radical thoracoscopic lung cancer surgery.
  • Patients were randomized (1:1) to receive either PHC (0.25 mg IV pre-anesthesia and 0.25 mg IV within 48h post-surgery) or normal saline (control).
  • Primary outcome: PONV incidence within 24h post-surgery. Secondary outcomes: PONV severity, patient/surgeon satisfaction (VAS), and adverse events (dry mouth, dizziness, etc.) within 48h.

Main Results:

  • The study hypothesizes that intravenous PHC administration will significantly decrease the incidence and severity of PONV.
  • Improved surgeon and patient satisfaction scores are anticipated with PHC treatment.
  • The safety profile of PHC, including common anticholinergic side effects, will be assessed.

Conclusions:

  • Intravenous PHC is hypothesized to be effective in reducing PONV after radical thoracoscopic lung cancer surgery.
  • PHC may enhance patient recovery and satisfaction, contributing to optimized postoperative care.
  • Findings could inform clinical practice guidelines for PONV management in this patient population.