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Targeted Cancer Therapies

Targeted Cancer Therapies

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Bioluminescent Bacterial Imaging In Vivo

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Published on: November 4, 2012

Dual-Membrane-Camouflaged Engineered Bacteria for Targeted Melanoma Therapy.

Ziqi Fang¹, Wenbin Zhong², Huihuang Xiong¹

¹School of Chemistry and Chemical Engineering, Nanchang University, Nanchang 330031, P. R. China.

|December 17, 2025

Summary

Engineered bacteria coated with dual membranes effectively target tumors, induce cancer cell death, and stimulate immune responses for enhanced cancer therapy. This novel approach overcomes limitations of traditional bacterial treatments.

Keywords:

AIF encoding antitumor immune response dual-cell-membrane modification engineered attenuated Salmonella tumor metastasis prevention

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Dual Bioluminescence Imaging of Tumor Progression and Angiogenesis

Dual Bioluminescence Imaging of Tumor Progression and Angiogenesis

Published on: August 1, 2019

Area of Science:

Biomedical Engineering
Cancer Therapy
Immunology

Background:

Bacteria offer potential in cancer therapy due to immune activation and genetic engineering.
Clinical use is limited by toxicity, rapid clearance, and low efficacy, necessitating functionalization.

Purpose of the Study:

To develop a dual-membrane-camouflaged bacterial therapeutic for improved cancer treatment.
To enhance tumor targeting, prolong circulation, and boost anti-tumor immunity.

Main Methods:

Fabrication of a dual-membrane-camouflaged bacterial therapeutic (VNP-AIF@Fe-TA@RH) using attenuated *Salmonella typhimurium*.
Engineered bacteria fused with red blood cell membrane (RM) and PD-1-overexpressing HEK293T cell membrane (HM).
Incorporation of apoptosis-inducing factor (AIF)-encoding plasmids and iron-tannic acid (Fe-TA) networks.

Main Results:

The VNP-AIF@Fe-TA@RH exhibited prolonged blood circulation and selective tumor accumulation.
In situ AIF expression induced tumor cell apoptosis and robust anti-tumor immune responses.
HM-mediated PD-L1 blockade reversed T cell dysfunction, remodeling the tumor immune microenvironment.

Conclusions:

The bacteria-based biohybrid therapeutic effectively inhibited melanoma tumor growth and metastasis.
This approach demonstrates significant potential for overcoming challenges in bacterial cancer therapy.
The study provides a novel strategy for designing effective cancer therapeutics.