Copper-catalyzed N-arylation of isatins employing aryl(TMP)-iodonium salts
Ankita Rakshit1, Raktim Abha Saikia2, Snata Deka1
1Department of Chemical Sciences, Tezpur University, Napaam-784028, India. ashim@tezu.ernet.in.
Abstract:
This work presents a general one-pot methodology for N-arylation of isatin functionalities employing aryl(2,4,6-trimethoxyphenyl)iodonium salts. The developed Cu-catalysed protocol works under mild conditions and is operationally straightforward. This synthetic approach demonstrates broad substrate scope, tolerating a wide range of electronically and sterically diverse aryl groups, thereby enabling access to a variety of N-arylated isatin products. Furthermore, two examples of post-synthetic modification highlight the utilization of the synthetic scaffolds.
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