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Tailoring layered double hydroxide nanomaterials through surface modification: design strategies and practical
1College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech, University, Nanjing 211816, China. 202321140045@njtech.edu.cn.
Nanoscale
|December 17, 2025
Summary
Surface modification of layered double hydroxides (LDHs) enhances their biomedical applications. Functionalized LDHs overcome limitations like aggregation, improving drug delivery and cancer therapy potential.
Area of Science:
- Materials Science
- Biomedical Engineering
- Nanotechnology
Background:
- Layered double hydroxides (LDHs) show promise in biomedicine due to their structure and biocompatibility.
- Pristine LDHs face challenges: particle aggregation, poor targeting, and immunogenicity.
- Surface functionalization is key to overcoming these limitations.
Purpose of the Study:
- To review LDH structure, properties, and modification rationale.
- To categorize and evaluate physical and chemical surface modification techniques.
- To highlight applications of modified LDHs in biomedicine.
Main Methods:
- Systematic review of LDH structural characteristics and properties.
- Analysis of surface modification techniques (e.g., BSA coating, silane grafting).
- Evaluation of modification mechanisms, efficacy, advantages, and limitations.
Main Results:
- Identified limitations of pristine LDHs in biomedical settings.
- Categorized and assessed various surface modification strategies.
- Demonstrated applications in stimuli-responsive drug release and precision therapy.
Conclusions:
- Surface modification is crucial for advancing LDH applications in biomedicine.
- Engineered LDHs offer potential for improved drug delivery and cancer therapy.
- Future research should focus on multifunctional and smart responsive LDH designs.
