Validating a pre-flight algorithm for predicting in-flight oxygen in patients with interstitial lung disease.
Lucy Robertson1, Karl P Sylvester1,2, Ben Knox-Brown1,2,3
1Royal Papworth Hospital, Respiratory Physiology Department, Cambridge, UK.
ERJ Open Research
|December 17, 2025
Summary
Resting partial pressure of oxygen (PaO2) above 9.30 kPa best predicts success on a hypoxic challenge test. This finding suggests blood gas analysis can determine fitness to fly without supplemental oxygen in interstitial lung disease.
Area of Science:
- Pulmonary Medicine
- Aviation Physiology
- Diagnostic Testing
Background:
- Interstitial lung disease (ILD) can impair gas exchange.
- Hypoxic challenge tests (HCT) assess the ability to tolerate low oxygen levels.
- Current methods for determining fitness to fly without supplemental oxygen can be complex.
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