Decoding cardiac metabolic reprogramming through single-cell multi-omics: from mechanisms to therapeutic applications

Area of Science:

• Cardiovascular Research
• Metabolomics
• Single-cell Biology

Background:

• Cardiac metabolic reprogramming is key in cardiovascular diseases.
• Traditional bulk omics have limitations in studying cellular metabolism.
• Single-cell technologies offer new insights into cardiac cell metabolism.

Purpose of the Study:

• To review advances in single-cell multi-omics for studying cardiac metabolism.
• To explore how metabolic reprogramming contributes to heart failure and myocardial infarction.
• To discuss metabolically targeted interventions and future clinical applications.

Main Methods:

• Single-cell transcriptomics
• Single-cell epigenomics
• Spatial transcriptomics

Main Results:

• Single-cell technologies enable detailed analysis of metabolic heterogeneity and intercellular communication in cardiac cells.
• Metabolic reprogramming is shown to drive the progression of heart failure and myocardial infarction.
• Emerging strategies target lactate shuttle, lipotoxicity, and immunometabolism.

Conclusions:

• Single-cell multi-omics provides unprecedented resolution for understanding cardiac metabolic diseases.
• Targeted metabolic interventions hold therapeutic potential for cardiovascular conditions.
• Translating these findings to clinical practice requires addressing challenges and fostering interdisciplinary collaboration for precision cardiology.