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Regulation of the microprocessor by post-translational modifications

Ka Weng Leong1,2, Mark M W Chong1,2

  • 1RNA and T cell Biology, St Vincent's Institute of Medical Research, Fitzroy, VIC, Australia.

Frontiers in Cell and Developmental Biology
|December 17, 2025
PubMed

Insights

Post-translational modifications (PTMs) of the Microprocessor complex, including DROSHA and DGCR8, are crucial for microRNA biogenesis. This review explores how PTMs like phosphorylation and ubiquitination regulate Microprocessor function and stability.

Area of Science:

  • Molecular Biology
  • Biochemistry

Background:

  • The Microprocessor complex, comprising DROSHA and DGCR8, initiates microRNA biogenesis.
  • Dysregulation of Microprocessor activity is linked to various diseases, including cancer and neurological disorders.

Purpose of the Study:

  • To review the known post-translational modifications (PTMs) of the Microprocessor complex.
  • To elucidate the functional roles of these PTMs in regulating Microprocessor activity and microRNA production.

Main Methods:

  • Literature review of studies on Microprocessor PTMs.
  • Focus on phosphorylation, acetylation, ubiquitination, and SUMOylation of DROSHA and DGCR8.

Main Results:

  • Multiple PTMs have been identified for DROSHA and DGCR8.
  • These modifications are implicated in regulating protein stability and microRNA processing.

Conclusions:

  • PTMs are critical regulators of Microprocessor function.
  • Further research is needed to fully characterize the functional impact of PTMs on microRNA biogenesis and associated diseases.
Keywords:
DGCR8DROSHASUMOylationacetylationmicroRNA biogenesismicroprocessorphosphorylationubiquitination

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