Corynebacterium Striatum Infective Endocarditis: A Systematic Review
Minghuan Hong1, Wei Xiang1, Lingyun Kong1
1Cardiovascular Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, People's Republic of China.
Journal of Inflammation Research
|December 17, 2025
Summary
Corynebacterium striatum infective endocarditis (CSIE) is a serious condition often misdiagnosed. CSIE has higher mortality and surgical intervention rates than common infective endocarditis, necessitating prompt clinical attention.
Area of Science:
- Infectious Diseases
- Cardiology
- Microbiology
Background:
- Corynebacterium striatum (CS) is an uncommon cause of infective endocarditis (IE).
- Limited literature exists on the clinical patterns and progression of CS infective endocarditis (CSIE).
- This study retrospectively analyzes documented CSIE cases to understand presentation and management.
Purpose of the Study:
- To elucidate the clinical presentation of CSIE.
- To analyze the management strategies for CSIE.
- To compare CSIE outcomes with IE caused by common pathogens.
Main Methods:
- Systematic electronic literature search across major databases (PubMed, CNKI, etc.).
- Extraction and analysis of patient-level data from identified articles.
- Retrospective case series analysis.
Main Results:
- 38 patients from 35 articles were analyzed; median age 68 years, 63.2% male.
- Mitral valve was the most affected site (52.8%); 28.9% misdiagnosis rate.
- Vancomycin showed efficacy; 41.7% of CS isolates were multidrug-resistant. Overall fatality rate was 37.8%.
Conclusions:
- CSIE often presents nonspecifically, leading to misdiagnosis.
- Advanced diagnostics like 16S rRNA and mNGS improve accuracy.
- CSIE has higher surgical intervention and mortality rates than common IE, requiring heightened clinical vigilance.
Related Concept Videos
01:25Endocarditis II: Clinical Features of Infective Endocarditis
371
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
371
01:25Endocarditis I: Introduction
362
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
362
01:18Endocarditis III: Medical Management
197
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
197
01:29Endocarditis IV: Nursing Management
297
Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
297
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
443
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
443
01:30Acute Coronary Syndrome III: Diagnostic Studies
197
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
197