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Structural Changes in Retinal Vein Occlusion: Implications for Functional Outcomes and Visual Field Deficits.

Christina Garnavou-Xirou1,2, Georgios Bontzos1, Tina Xirou1

  • 1Department of Ophthalmology, Korgialenio-Benakio General Hospital, Athens, Greece.

Maedica
|December 17, 2025
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Summary

Structural retinal changes like atrophy and neovascularization are linked to visual field defects in branch retinal vein occlusion (BRVO). Comprehensive functional assessments are crucial for managing BRVO patients.

Keywords:
branch retinal vein occlusionoptical coherence tomographyretinal atrophyretinal neovascularizationvisual field defects

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Area of Science:

  • Ophthalmology
  • Retinal Vascular Diseases
  • Visual Neuroscience

Background:

  • Branch retinal vein occlusion (BRVO) can cause significant visual impairment.
  • Understanding the link between structural retinal damage and visual field (VF) deficits is crucial for patient management.

Purpose of the Study:

  • To investigate the relationship between structural retinal changes and functional VF deficits in BRVO patients.
  • To identify potential imaging biomarkers for predicting visual impairment in BRVO.

Main Methods:

  • Cross-sectional study of 34 unilateral BRVO patients.
  • Ophthalmic examinations included visual acuity, IOP, OCT, OCT-A, and fundus photography.
  • Retinal alterations and VF defects were assessed; logistic regression analyzed associations.

Main Results:

  • 26.5% of patients had VF defects.
  • Retinal atrophy and neovascularization were more common in patients with VF defects.
  • No statistically significant predictors were identified in univariate or multivariate analyses, though trends were observed.

Conclusions:

  • Structural retinal changes (atrophy, neovascularization) are associated with VF defects in BRVO.
  • Comprehensive functional assessments are important, even without statistically significant predictors.
  • Future VF testing technologies may improve early detection and management of BRVO-related functional deficits.