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Hippo Signaling Transduction Pathway Deregulation in Eye Diseases.

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|December 17, 2025
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Summary

The Hippo signaling pathway, crucial for cell function, is deregulated in various eye diseases. This deregulation impacts key proteins like TAZ, LATS, and YAP1, contributing to lesion development.

Keywords:
HippoLATSTAZYAP1eyesignaling pathway

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Area of Science:

  • Cellular signaling pathways
  • Molecular biology
  • Ophthalmology

Background:

  • The Hippo pathway is a conserved signaling network regulating cell proliferation, apoptosis, and organ size.
  • Core components include MST1/2, SAV1, MOB1A/B, and LATS1/2, with YAP/TAZ acting as transcriptional coactivators.
  • Dysregulation of the Hippo pathway is implicated in various diseases.

Purpose of the Study:

  • To review the molecular and functional aspects of the Hippo pathway.
  • To describe its deregulation in specific eye lesions.

Main Methods:

  • Systematic literature review of PubMed articles, focusing on publications since 2005.
  • Keywords used: Hippo, TAZ, LATS, YAP1, eye, signaling pathway.
  • Selection of 70 key articles detailing Hippo pathway molecules, functions, and deregulation in eye pathogenesis.

Main Results:

  • Hippo pathway deregulation is evident across a range of benign and neoplastic eye diseases.
  • TAZ, LATS, and YAP1 protein functions are negatively affected by core Hippo molecule deregulation.
  • Specific lesions include retina- and lens-related conditions, conjunctival fibrosis, and ocular surface squamous neoplasia.

Conclusions:

  • Hippo pathway deregulation is a critical factor in the pathogenesis of numerous ocular conditions.
  • Genetic mechanisms involve YAP/TEAD point mutations and altered expression of other pathway molecules.