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Related Experiment Video

Updated: Jan 8, 2026

Author Spotlight: Advancing VRL Diagnosis Using Cell-Free DNA Extraction from Vitreous Humor

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Published on: January 12, 2024

Intraocular Lymphoma: A Review.

Saeed Karimi¹, Kimia Daneshvar¹

¹Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Journal of Ophthalmic & Vision Research

|December 17, 2025

Summary

Intraocular lymphoma (IOL) is a rare cancer affecting the eye, often mimicking other conditions. Early diagnosis using advanced lab tests and imaging is crucial for effective treatment and better patient outcomes.

Keywords:

Masquerade Syndromes Uveal Lymphoma Vitreoretinal Lymphoma Intraocular Lymphoma

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Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

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Published on: December 2, 2022

Area of Science:

Ophthalmology
Oncology
Hematology

Background:

Intraocular lymphoma (IOL) is a rare non-Hodgkin lymphoma, with primary (PIOL) and secondary (SIOL) types.
PIOL is often a subtype of primary central nervous system lymphoma (PCNSL), with increasing incidence in various populations.
Diagnosis is challenging due to mimicry of other ocular diseases, necessitating advanced diagnostic approaches.

Purpose of the Study:

To provide a comprehensive review of intraocular lymphoma.
To detail the clinical manifestations and diagnostic methods for IOL.
To emphasize the importance of accurate and timely diagnosis for patient outcomes.

Main Methods:

Review of current literature on intraocular lymphoma.
Discussion of diagnostic advancements including immunocytochemistry, flow cytometry, and PCR.
Highlighting the role of multimodal imaging and molecular analyses.

Main Results:

IOL presents as PIOL or SIOL, with PIOL commonly linked to PCNSL.
Diffuse large B-cell lymphoma is the most frequent type of PIOL.
Advanced diagnostics like interleukin ratios and PCR improve diagnostic accuracy.

Conclusions:

Accurate diagnosis of IOL is critical to avoid treatment delays and improve prognosis.
Multimodal imaging and molecular analyses aid in predicting visual prognosis and recurrence.
Understanding IOL's clinical features and diagnostic tools is essential for ophthalmologists and pathologists.