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A High-throughput-compatible FRET-based Platform for Identification and Characterization of Botulinum Neurotoxin Light Chain Modulators

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Chronic Botulism in Humans: A Case Series.

Minoosh Shabani Barzegar¹, Sara Pourhemmati², Masoud Mardani¹

¹Department of Infectious Disease, School of Medicine Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences Tehran Iran.

Clinical Case Reports

|December 17, 2025

Summary

This study details unusual botulism cases in humans and goats from one farm, linked to animal visceral botulism. Persistent weight loss and weakness were key signs, though less severe than typical botulism.

Keywords:

Clostridium botulinum botulism case series human botulism neurologic manifestation weight loss

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Area of Science:

Veterinary Medicine
Clinical Neurology
Infectious Diseases

Background:

Botulism is a rare but serious paralytic illness caused by toxins produced by Clostridium botulinum bacteria.
Typical botulism presentations involve descending muscle paralysis, potentially leading to respiratory failure.
Animal visceral botulism, particularly in livestock, can serve as a potential source of human infection.

Purpose of the Study:

To describe novel clinical manifestations of botulism observed concurrently in humans and goats from a single farm.
To investigate the potential link between human botulism cases and animal visceral botulism within the same environment.
To characterize the specific symptoms, focusing on atypical presentations and severity.

Main Methods:

Clinical case observation and symptom documentation in affected human patients.
Veterinary examination and diagnostic assessment of affected goats on the farm.
Epidemiological investigation to establish potential transmission links and common sources.

Main Results:

Concurrent onset of botulism symptoms in human patients and goats residing on the same farm was documented.
Persistent clinical signs included significant weight loss and generalized weakness in both species.
The observed symptoms, while characteristic of botulism, were notably less severe and not immediately life-threatening compared to typical presentations.

Conclusions:

The findings suggest a potential association between human botulism cases and animal visceral botulism, possibly originating from a shared environmental source.
The study highlights atypical, non-life-threatening clinical presentations of botulism, emphasizing the importance of considering milder forms in diagnosis.
Further research is warranted to elucidate the specific transmission dynamics and the factors contributing to the observed variations in botulism severity.