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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Advancing Epigenetic Combination Therapy in Oncology: Multifunctional Nano-Drug Delivery Systems for Synergistic

Tong Gao1, Shunli Fu2, Xianghua Quan1

  • 1Department of Pharmacy, the Affiliated Hospital of Qingdao University, Qingdao, 266000, People's Republic of China.

International Journal of Nanomedicine
|December 17, 2025
PubMed

Insights

This review explores how nano-drug delivery systems (NDDS) can improve epigenetic combination therapies for cancer. Multifunctional NDDS offer precise control over drug delivery, enhancing treatment efficacy and paving the way for personalized cancer care.

Area of Science:

  • Oncology
  • Nanotechnology
  • Pharmacology

Background:

  • Epigenetic modifications are crucial in cancer development and progression.
  • Epigenetic combination therapies show promise but face challenges with drug pharmacokinetics and biodistribution.
  • Nano-drug delivery systems (NDDS) offer potential for co-delivery and pharmacokinetic optimization.

Purpose of the Study:

  • To review the mechanisms of epigenetic dysregulation in cancer.
  • To analyze current epigenetic combination therapies and their limitations.
  • To highlight the role of multifunctional NDDS in advancing epigenetic combination therapy for precision cancer treatment.

Main Methods:

  • Literature review of epigenetic dysregulation mechanisms.
  • Analysis of existing epigenetic combination strategies in oncology.
  • Exploration of NDDS design principles for co-delivery and pharmacokinetic modulation.
  • Discussion of multifunctional NDDS for precise therapeutic regulation.

Main Results:

  • Epigenetic dysregulation drives tumorigenesis, making epigenetic therapies a key focus.
  • NDDS can overcome pharmacokinetic and biodistribution challenges in combination therapies.
  • Multifunctional NDDS enable precise control over therapeutic agent delivery for enhanced cancer treatment.

Conclusions:

  • Innovative NDDS designs are crucial for the clinical translation of epigenetic combination therapies.
  • Multifunctional NDDS hold significant potential for personalized cancer treatment.
  • Future advancements in AI-driven NDDS, biomimetic carriers, and epigenetic editing will further personalize cancer therapy.
Keywords:
cancer combination therapyepigeneticsmultifunctional drug delivery strategynano-drug delivery systems

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