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GWAS and Replication Analysis of Apparent Treatment-Resistant Hypertension.

Joseph E Ebinger1, Anni Kauko2,3, Felix Vaura4

  • 1Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (J.E.E., S.Y.J., S.C.).

Hypertension (Dallas, Tex. : 1979)
|December 17, 2025
PubMed
Summary

Resistant hypertension (RH) has distinct genetic drivers, including those related to aldosterone homeostasis and vascular function. Identifying these genetic variants offers new targets for treating RH and reducing cardiovascular risks.

Keywords:
Mendelian randomization analysisgenome-wide association studyhyperaldosteronismhypertensionvascular remodeling

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