Pharmacokinetic-Driven Individualized Anticoagulation Plan for Pediatric Athletes on Direct Oral Anticoagulants
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View abstract on PubMed
Summary
This summary is machine-generated.Children on anticoagulation can safely participate in contact sports with individualized plans. Pharmacokinetic data guided safe management, with no major bleeding events observed during sports participation or injury management.
Area Of Science
- Pediatric Hematology
- Sports Medicine
- Pharmacology
Background
- Children on anticoagulation are often restricted from contact sports due to bleeding concerns.
- Direct oral anticoagulants (DOACs) offer predictable pharmacokinetics for tailored treatment.
Purpose Of The Study
- To assess the safety and feasibility of individualized anticoagulation plans for pediatric athletes in contact sports.
- To evaluate the use of pharmacokinetic (PK) data in managing anticoagulation for young athletes.
Main Methods
- Individualized anticoagulation plans were developed using PK data for five pediatric athletes.
- Patients were followed for a median of 27 months, including periods of anticoagulation interruption for sports injuries.
Main Results
- Two patients experienced four sports-related injuries during anticoagulation interruption.
- No clinically significant bleeding or recurrent thrombosis occurred.
- All patients safely resumed anticoagulation after injury.
Conclusions
- Individualized anticoagulation management based on PK data enables pediatric athletes to participate in contact sports.
- This approach appears safe, with no major bleeding complications observed.
- Careful management allows for safe resumption of anticoagulation post-injury.
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