Related Experiment Video

Updated: Jan 8, 2026

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
11:17

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Published on: October 12, 2012

14.3K

Pharmacokinetic-Driven Individualized Anticoagulation Plan for Pediatric Athletes on Direct Oral Anticoagulants

Devin Donnelly1, Riten Kumar1,2

  • 1Dana Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, USA.

Pediatric Blood & Cancer
|December 17, 2025
PubMed

Insights

Children on anticoagulation can safely participate in contact sports with individualized plans. Pharmacokinetic data guided safe management, with no major bleeding events observed during sports participation or injury management.

Area of Science:

  • Pediatric Hematology
  • Sports Medicine
  • Pharmacology

Background:

  • Children on anticoagulation are often restricted from contact sports due to bleeding concerns.
  • Direct oral anticoagulants (DOACs) offer predictable pharmacokinetics for tailored treatment.

Purpose of the Study:

  • To assess the safety and feasibility of individualized anticoagulation plans for pediatric athletes in contact sports.
  • To evaluate the use of pharmacokinetic (PK) data in managing anticoagulation for young athletes.

Main Methods:

  • Individualized anticoagulation plans were developed using PK data for five pediatric athletes.
  • Patients were followed for a median of 27 months, including periods of anticoagulation interruption for sports injuries.

Main Results:

  • Two patients experienced four sports-related injuries during anticoagulation interruption.
  • No clinically significant bleeding or recurrent thrombosis occurred.
  • All patients safely resumed anticoagulation after injury.

Conclusions:

  • Individualized anticoagulation management based on PK data enables pediatric athletes to participate in contact sports.
  • This approach appears safe, with no major bleeding complications observed.
  • Careful management allows for safe resumption of anticoagulation post-injury.

Keywords:
anticoagulation therapypediatric hematology/oncologypharmacokinetics

More Related Videos

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

84.3K
Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System12:40

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Published on: December 7, 2012

29.4K

Related Concept Videos

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
2.0K
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
194
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
262
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
231
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
240
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.6K