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Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...

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Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

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Why doesn't neuroimaging work in psychiatry?

Robert A McCutcheon^1,2,3, Sameer Jauhar⁴, Toby Pillinger^3,5

¹Department of Psychiatry, https://ror.org/052gg0110University of Oxford, Oxford, UK.

The British Journal of Psychiatry : the Journal of Mental Science

|December 17, 2025

Summary

This summary is machine-generated.

Neuroimaging has advanced psychiatric disorder understanding but not clinical practice. Future psychiatric research requires integrated brain, behavior, and treatment imaging approaches, not just new tools.

Keywords:

MRI Neuroimaging biomarkers diagnosis and classification precision medicine

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Area of Science:

Neuroscience
Psychiatry
Medical Imaging

Background:

Neuroimaging has significantly advanced the understanding of psychiatric disorders over the past 50 years.
Despite these advancements, the translation of neuroimaging findings into clinical practice for psychiatric disorders has been limited.

Purpose of the Study:

To examine the reasons behind the unfulfilled promise of neuroimaging in psychiatric clinical practice.
To propose a future direction for psychiatric imaging research that bridges the gap between neuroscience and clinical application.

Main Methods:

Critical review of the historical impact and current limitations of neuroimaging in psychiatry.
Analysis of the disconnect between neuroimaging research and clinical utility.
Conceptual framework development for future imaging approaches.

Main Results:

The gap between neuroimaging insights and clinical practice persists due to a lack of mechanistic grounding and clinical integration.
Current neuroimaging tools, while advancing, have not sufficiently addressed the complexity of psychiatric disorders in real-world clinical settings.

Conclusions:

The future of psychiatric neuroimaging lies in developing rigorous, mechanistically informed, and clinically embedded approaches.
Future research should focus on integrating brain data with behavioral and treatment outcomes to enhance clinical practice for psychiatric disorders.