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Updated: Jan 8, 2026
08:47
Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells
Published on: May 1, 2020
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Eukaryotic translation initiation factor 4F: functional properties and physiological role.
Ekaterina Shuvalova1, Walaa Al Sheikh1,2, Alexey Shuvalov1
1Engelhardt Institute of Molecular Biology, the Russian Academy of Sciences, Moscow, 119991, Russia.
Nucleic Acids Research
|December 17, 2025
Summary
The eukaryotic initiation factor 4F (eIF4F) complex is crucial for protein translation initiation. This review explores eIF4F
Area of Science:
- Molecular Biology
- Cellular Biology
- Biochemistry
Background:
- Translation initiation is a highly regulated process.
- The eukaryotic initiation factor 4F (eIF4F) complex plays a key role in this regulation.
- eIF4F consists of eIF4E, eIF4A, and eIF4G subunits.
Purpose of the Study:
- To review the roles of eIF4F in translation.
- To discuss its regulatory functions in various cellular conditions.
- To highlight unresolved questions regarding its mechanistic contributions.
Main Methods:
- Literature review of existing studies on eIF4F.
- Analysis of eIF4F's structure and function.
- Examination of eIF4F's involvement in cellular regulation.
Main Results:
- eIF4F is central to the tightly regulated initiation of translation.
- Dysregulation of eIF4F is linked to numerous physiological abnormalities.
- Recent research positions eIF4F as a global cellular regulator.
Conclusions:
- eIF4F is critical for cellular function and translational control.
- Further research is needed to fully understand eIF4F's mechanistic roles.
- eIF4F's function extends beyond translation initiation, impacting global cellular regulation.
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