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Related Concept Videos

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In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
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In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
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Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
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Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Paediatrics
  9. Infant And Child Health
  11. Impact Of Hepcidin-25 Biomarker On Antioxidant Status And Trace Elements In Pediatric Iron Deficiency.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Paediatrics
  9. Infant And Child Health
  11. Impact Of Hepcidin-25 Biomarker On Antioxidant Status And Trace Elements In Pediatric Iron Deficiency.

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Impact of Hepcidin-25 Biomarker on Antioxidant Status and Trace Elements in Pediatric Iron Deficiency.

Mhabad Khorsheed Saeed1, Lina Yousif Mohammed2

  • 1Department of Chemistry, College of Science, University of Zakho, Zakho, Iraq.

Journal of the American Nutrition Association
|December 17, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Serum hepcidin-25 is significantly lower in children with early iron deficiency (EID) and iron deficiency anemia (IDA), indicating its role as a biomarker for iron deficits. This suppression affects trace elements and antioxidant activities.

Keywords:
Antioxidantshepcidin-25 biomarkeriron deficiencyoxidative stress

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Area of Science:

  • Pediatric Hematology
  • Nutritional Biochemistry
  • Biomarker Discovery

Background:

  • Iron deficiency is prevalent in children, impacting iron metabolism and overall health.
  • Hepcidin-25 is a key regulator of iron homeostasis, but its role in pediatric iron deficiency states requires further elucidation.
  • Antioxidant defense mechanisms and trace element status are often compromised in iron-deficient children.

Purpose of the Study:

  • To investigate the regulatory role of serum hepcidin-25 in children with early iron deficiency (EID) and iron deficiency anemia (IDA).
  • To evaluate the relationship between serum hepcidin-25, iron profile, trace elements (zinc, copper, magnesium), and antioxidant markers (catalase, glutathione-S-transferase, superoxide dismutase).

Main Methods:

  • A cross-sectional study involving 90 children aged 2-10 years, categorized into control, EID, and IDA groups.
trace elements
  • Assessment of hematological parameters, iron profile, serum hepcidin-25, trace elements (Zn, Cu, Mg), and antioxidant markers (CAT, GST, SOD).

    • Main Results:

    • Serum hepcidin-25 levels were significantly lower in both EID and IDA groups compared to controls.
    • Reduced levels of zinc, catalase (CAT), and superoxide dismutase (SOD) were observed in EID and IDA groups.
    • Magnesium (Mg) and glutathione-S-transferase (GST) levels were significantly decreased in the IDA group.
    • Serum hepcidin-25 positively correlated with serum iron, transferrin saturation, zinc, magnesium, SOD, and CAT.

    Conclusions:

    • Suppressed serum hepcidin-25 serves as a reliable indicator of iron deficits in children.
    • Iron deficiency, as indicated by low hepcidin-25, is associated with disturbances in trace element concentrations and antioxidant activities.
    • Hepcidin-25 plays a crucial regulatory role in the systemic response to iron deficiency in pediatric populations.