Cardiometabolic index as a novel prognostic biomarker for cardiovascular events in post-percutaneous coronary

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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

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Liu Yehong1, Liu Yan1, Chen Ke2

  • 1The 904th Hospital of Joint Logistic Support Force of PLA, Wuxi, Jiangsu, People's Republic of China.

Current Medical Research and Opinion
|December 17, 2025
PubMed

Insights

The Cardiometabolic Index (CMI) predicts major adverse cardiovascular events (MACEs) in ST-segment elevation myocardial infarction (STEMI) patients, with inflammation playing a mediating role. This marker aids in assessing long-term outcomes for STEMI survivors.

Area of Science:

  • Cardiology
  • Metabolic Syndrome
  • Biomarkers

Background:

  • The Cardiometabolic Index (CMI) is a known metabolic marker.
  • Its predictive value for major adverse cardiovascular events (MACEs) in ST-segment elevation myocardial infarction (STEMI) patients requires further investigation.
  • Inflammation's role in mediating these outcomes is also of interest.

Purpose of the Study:

  • To evaluate the predictive capability of CMI for long-term MACEs in STEMI patients.
  • To explore the mediating effects of inflammatory markers on the association between CMI and adverse cardiovascular outcomes.
  • To assess CMI as a prognostic tool in STEMI management.

Main Methods:

  • Analysis of data from 785 STEMI patients who underwent primary percutaneous coronary intervention.
  • Primary endpoint: composite of cardiovascular death, non-fatal myocardial infarction, revascularization, and heart failure rehospitalization.
  • Statistical analysis included Cox regression and mediation analysis using the lymphocyte to C-reactive protein ratio (LCR).

Main Results:

  • Elevated CMI was significantly associated with increased risk of MACEs (HR: 4.584), non-fatal myocardial infarction (HR: 2.142), revascularization (HR: 7.911), and heart failure rehospitalization (HR: 6.243).
  • No significant association was found between CMI and cardiovascular death.
  • LCR partially mediated the relationship between CMI and MACEs/heart failure rehospitalization (-13.7% and -19.5%, respectively).

Conclusions:

  • Elevated CMI is a significant predictor of MACEs and heart failure rehospitalization in STEMI patients.
  • Inflammatory pathways, indicated by LCR, partially mediate the prognostic impact of CMI.
  • CMI shows potential as a valuable prognostic biomarker for STEMI patients.
Abstract

Keywords:
Cardiometabolic indexST-segment elevation myocardial infarctionatherogenic index of plasmalymphocyte to C-reactive protein ratiomajor adverse cardiovascular eventstriglyceride-glucose index

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