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Phase III Data Support Chemo-Free Approach to ALL

    Cancer Discovery
    |December 17, 2025
    PubMed

    Abstract:

    In the phase III GIMEMA ALL2820 trial, treatment with ponatinib and blinatumomab led to significantly better response rates and overall survival than a chemotherapy-imatinib regimen for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. The findings could change the standard of care for the disease.

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