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Diagnostic performance of serum MMP-7 in biliary atresia: a systematic review and meta-analysis
Jun-Ni Ma1, Meng-Xin Zhang, Shui-Qing Chi
1Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Objective:
Serum matrix metalloproteinase-7 (MMP-7) has been increasingly utilized in the detection of biliary atresia (BA). However, its diagnostic efficacy remains controversial. This study aims to clarify the value of MMP-7 in diagnosing BA.
Materials And Methods:
A systematic search of PubMed, Web of Science, Embase, Cochrane Library, and Scopus from database inception to 1 September 2025 was performed. Main outcomes were sensitivity, specificity, diagnostic odds ratio (DOR), and mean area under the summary receiver operating characteristic curve (AUC). I2 was used to evaluated heterogeneity, meanwhile meta-regression and subgroup analyses were adopted to investigated the source of heterogeneity.
Results:
Seventeen studies with 2784 patients with BA were included. The pooled sensitivity, specificity, DOR, and AUC were 0.93 (95% CI, 0.91-0.95), 0.90 (95% CI, 0.86-0.93), 123.77 (95% CI, 75.45-203.02) and 0.97 (95% CI, 0.95-0.98) respectively. Meta-regression showed that study type, study area, sample size, detection method and age were the main sources of heterogeneity (P < .05). Subgroup analyses showed higher pooled DOR in cohorts of infants < 60 days vs. unrestricted age (183.32 vs. 108.75), in prospective studies vs. retrospective study (348.74 vs. 101.58), and in Eastern vs. Western countries (149.83 vs. 51.15).
Conclusion:
The findings indicated that MMP-7 maintained outstanding diagnostic accuracy for BA and should be recommended as primary routine diagnostic strategy for patients with BA, particularly for infants under two months of age.
