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Related Concept Videos

Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

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Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
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Acute Pancreatitis I: Introduction01:27

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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
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Chronic Pancreatitis II: Collaborative Care01:29

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
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Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Diabetes: Symptoms, Diagnosis, and Complications01:15

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For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
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Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
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Related Experiment Video

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Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
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Predicting New-onset Diabetes Following Acute Pancreatitis: The CAPS Score.

Harry Trieu1, Aneesa Chowdhury1, Jennifer Dodge1,2

  • 1Division of Gastroenterology, Department of Internal Medicine, University of Southern California Keck School of Medicine.

Pancreas
|December 17, 2025
PubMed
Summary

Researchers identified key factors to predict diabetes mellitus after acute pancreatitis. The CAPS score, using cirrhosis history, albumin, prediabetes, and pancreatitis severity, helps identify at-risk patients.

Keywords:
acute pancreatitisdiabetes mellitusmetabolic syndromeseverity

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Area of Science:

  • Endocrinology
  • Gastroenterology
  • Clinical Prediction Modeling

Background:

  • Postpancreatitis diabetes mellitus (PPDM-A) is a severe complication of acute pancreatitis.
  • Identifying risk factors for PPDM-A is crucial for early intervention.

Purpose of the Study:

  • To identify risk factors for PPDM-A.
  • To develop a predictive model for PPDM-A in patients with acute pancreatitis.

Main Methods:

  • Prospective cohort study of 891 adult patients with acute pancreatitis.
  • Logistic regression with best subset selection used to build a predictive model.
  • Model validated on an 80:20 training-validation split.

Main Results:

  • PPDM-A developed in 7.0% of patients at a median of 27.8 months post-admission.
  • The optimal predictive model (CAPS score) included cirrhosis history, serum albumin, prediabetes history, and pancreatitis severity.
  • The CAPS score achieved an AUROC of 0.631 in the validation cohort.

Conclusions:

  • A predictive score (CAPS) using readily available clinical data can identify patients at risk for diabetes mellitus following acute pancreatitis.
  • Further validation and refinement in larger cohorts are recommended.