Sedentary behavior and risk of incident kidney stone disease: a retrospective analysis on population-based cohort...

This study aimed to examine the longitudinal association between sedentary behavior, assessed via accelerometer or self-reported questionnaires, and the risk of kidney stone disease.

In this retrospective analysis on UK Biobank study, subjects were excluded if they had baseline kidney stone disease, lacked data on sedentary behavior, had sedentary time ≥18 hours/day, or lacked genetic data (for genetic interaction analysis). Sedentary time was assessed using self-report questionnaires or accelerometer. The polygenic risk score for kidney stone disease was derived from 15 single-nucleotide polymorphisms. Hospital records and official death records were used to identify incident kidney stone disease cases.

For analysis regarding sedentary time assessed via self-report questionnaires, this study included 498 476 participants (mean age 56.5 ± 8.1 years; 54.6% female). During a median follow-up of 13.8 years, 6 079 incident kidney stone diseases were documented. Compared to low sedentary time, the multivariable-adjusted hazard ratios (HRs) of kidney stone disease were 1.16 (95% CI: 1.07, 1.26) and 1.37 (95% CI: 1.26, 1.50) for p intermediate sedentary time and high sedentary time, respectively. For the analysis regarding sedentary time assessed by accelerometer, we included 92 775 participants (mean age 61.9 ± 7.9 years, 56.6% female). During a median follow-up of 7.9 years, 615 incident kidney stone diseases were identified. Compared to low sedentary time, the multivariable-adjusted HRs of kidney stone disease was 1.44 (95% CI: 1.04, 2.00) for high sedentary time. In genetic interaction analysis, those with high sedentary time and the highest tertile of polygenic risk score had the highest risk of kidney stone disease (for self-report sedentary time: HR 2.34, 95% CI: 1.99, 2.75; for accelerometer assessed sedentary time: HR 3.94, 95% CI: 2.20, 7.08) compared with those with low sedentary time and the lowest tertile of polygenic risk score.

Sedentary time, whether assessed by questionnaire or measured by accelerometer, was independently associated with incident kidney stone disease.