An in vitro organ-on-chip model for studying neuron-keratinocyte interactions in sensory response through...

This study introduces a human-relevant in vitro model using iPSC-derived sensory neurons and keratinocytes in MEA-integrated microfluidic chips. Neurons expressed nociceptor markers, showed TRPV activity, and formed contacts with keratinocytes. Stimuli evoked electrophysiological responses, highlighting neuron-keratinocyte interactions relevant to pruritus, pain, and skin disorders, supporting therapeutic development.