[Case of Successful Desensitization with Temozolomide in a Patient with Severe Skin Reaction]

Patient diagnosed with glioblastoma multiforme undergoing adjuvant treatment with temozolomide, on the 4th day of the seventh adjuvant cycle, developed a widespread erythematous maculopapular rash on the abdomen, back, chest, and facial area. Due to the severity of the condition and the risk of experiencing a similar dermatological reaction, a desensitization protocol with temozolomide was decided to realize based on successful cases worldwide. The patient successfully completed the initially planned 12 treatment cycles, 5 of which involved the desensitization protocol, with only mild symptoms during the first desensitization cycle. Temozolomide desensitization is a successful and safe procedure that enables patients to continue their treatment.